カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Dosimetric analysis of intraocular hemorrhage in nonsquamous head and neck cancers treated with carbon-ion radiotherapy
掲載誌名	正式名：Radiotherapy and Oncology ISSNコード：0167-8140
掲載区分	国外
出版社	Elsevier BV
巻・号・頁	170,143-150頁
著者・共著者	Ankita Nachankar,Atsushi Musha,Nobuteru Kubo,Hidemasa Kawamura,Naoko Okano,Hiro Sato,Kohei Okada,Akiko Adachi,Tatsuya Ohno
発行年月	2022/03
概要	BACKGROUND AND PURPOSE: Carbon-ion radiotherapy is an attractive treatment option for unresectable/inoperable, nonsquamous cancers of the head and neck. Intraocular hemorrhage associated with carbon-ion radiotherapy for head and neck cancer is largely an unresearched area; hence, we investigated its incidence and predictive factors. MATERIAL AND METHODS: We evaluated 79 patients (i.e., 158 eyes) with nonsquamous cancers of the head and neck treated by carbon-ion radiotherapy with a follow-up period of ≥12 months. Dosimetric parameters such as Dmax, Dmean and Vd [volume irradiated with "d" Gy (RBE)] and age, gender, primary site, histology and comorbidities were analyzed as predictors of intraocular hemorrhage. RESULTS: Seven (8.9%) of 79 patients (158 eyes) developed intraocular hemorrhage with a median latent period of 24 months (range, 15-47 months). The 5-year cumulative incidence of intraocular hemorrhage was 6%. Dmax and V10-60 for eyeballs, retina and optic nerves were significantly higher in intraocular hemorrhage group than the rest (p < 0.001 for Dmax and V10-60). On univariate analysis, V40 ≥ 0.83 cm3 and 0.66 cm3 (p = 0.001) and Dmax ≥ 54.75 Gy (RBE) and ≥ 54.58 Gy (RBE) (p = 0.002) for eyeball and retina, respectively, were predictors of intraocular hemorrhage. Additionally, maxillary primary (p = 0.025) and younger age (age < 60 years, p = 0.048) were significant risk factors for intraocular hemorrhage. CONCLUSIONS: Dosimetric parameters such as V40 and Dmax for the eyeball, retina and maxillary sinus primary and younger age were significant predictors of intraocular hemorrhage following carbon-ion radiotherapy.
DOI	10.1016/j.radonc.2022.02.032
PMID	35257851