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カワムラ ヒデマサ
KAWAMURA Hidemasa
河村 英将 所属 埼玉医科大学 医学部 総合医療センター 放射線科(画像診断・核医学科、放射線腫瘍科) 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | The Efficacy of Radiotherapy without Surgery for External Auditory Canal Squamous Cell Carcinoma |
| 掲載誌名 | 正式名：Journal of Clinical Medicine ISSNコード：2077-0383 |
| 掲載区分 | 国外 |
| 出版社 | MDPI AG |
| 巻・号・頁 | 11(19),5905-5905頁 |
| 著者・共著者 | Naoto Osu,Atsushi Musha,Hikaru Yumisaki,Kohei Okada,Nobuteru Kubo,Naoko Okano,Yukihiko Takayasu,Masato Shino,Osamu Nikkuni,Shota Ida,Hidemasa Kawamura,Kazuaki Chikamatsu,Tatsuya Ohno |
| 発行年月 | 2022/10/06 |
| 概要 | External auditory canal (EAC) cancer is a rare disease for which there are no adequate evidence-based treatment strategies. Radiotherapy is often used as the initial treatment to preserve the organ. This study aimed to elucidate the efficacy of radiotherapy for EAC squamous cell carcinoma (SCC). Patients with T1 disease were treated with radiotherapy alone. Patients with T2-4 disease were treated with chemoradiotherapy. The median follow-up period was 30.4 months. The 3-year local control (LC) rate for all patients was 51%, the disease-free survival (DFS) rate was 44%, and the overall survival (OS) rate was 73%. For T1-3 disease, the 3-year LC rate was 74%, DFS was 62%, and OS was 89%. However, for T4 disease, the 3-year LC rate was 17%, DFS was 17%, and OS was 50%. In a univariate analysis, only the T-category was a significant factor for LC and DFS (p = 0.006 and 0.02, respectively). All local recurrences were within the high-dose irradiated area. The results of this study suggest chemoradiotherapy can be an alternative to a combination of surgery and postoperative radiation for T1-3 SCC of the EAC. However, the efficacy of chemoradiotherapy in T4 cases was inadequate. |
| DOI | 10.3390/jcm11195905 |
| PMID | 36233771 |
| PermalinkURL | https://www.mdpi.com/2077-0383/11/19/5905/pdf |