タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion
掲載誌名	正式名：Biochemical and Biophysical Research Communications ISSNコード：0006-291X
出版社	Academic Press Inc.
巻・号・頁	287(2),501-506頁
著者・共著者	Masaya Ueno,Katsuhide Igarashi,Naoki Kimura,Keisuke Okita,Makiko Takizawa,Ikuo Nobuhisa,Tetsuo Kojima,Toshio Kitamura,Ulrike Samulowitz,Dietmar Vestweber,Taizo Shimomura,Toshio Suda,Kinichi Nakashima,Tetsuya Taga
発行年月	2001/09/21
概要	Recent studies have suggested the existence of progenitors common to hematopoietic and endothelial cells, called hemangioblasts, in, for instance, embryonic dorsal aorta. To identify a membrane-bound or secretory molecule regulating early hematopoiesis, we screened a cDNA library from dorsal aortas of embryonic day (E) 10.5 mice by a signal sequence trap method and obtained a clone encoding a sialoprotein, endomucin-1. Immunohistochemistry revealed that the endomucin-1 transcript was specifically expressed in the endothelial cells of dorsal aorta of E10.5 mouse embryo. Overexpression of endomucin-1 strongly inhibited adhesion and aggregation of cells, including cultured endothelial cells from E10.5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis. © 2001 Academic Press.
DOI	10.1006/bbrc.2001.5587
PMID	11554756