タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Pericardial graft vs. host disease in a patient with myelodysplastic syndrome following peripheral blood stem cell transplantation.
掲載誌名	正式名：European journal of haematology ISSNコード：0902-4441
掲載区分	国外
巻・号・頁	75(1),65-7頁
著者・共著者	Yasuyuki Saito,Takafumi Matsushima,Noriko Doki,Yuki Tsumita,Makiko Takizawa,Akihiko Yokohama,Hiroshi Handa,Norifumi Tsukamoto,Masamitsu Karasawa,Hirokazu Murakami,Yoshihisa Nojima
発行年月	2005/07
概要	A patient with myelodysplastic syndrome developed pericardial effusion 20 month after allogenic peripheral blood stem cell transplantation. Sclerotic and erythematous skin lesions were observed over the face and extremities, and a diagnosis of chronic graft vs. host disease (GVHD) was made based on skin biopsy findings. Pericardial fluid contained numerous CD8+/HLA-DR+ lymphocytes, but no leukaemic cells. Tumour necrosis factor alpha (TNFalpha) and soluble Fas (sFas) levels were highly elevated in both the effusion and serum. The patient was treated with methylprednisolone and tacrolimus. Skin GVHD improved rapidly associated with resolution of pericardial effusion and reductions in cytokine levels. We concluded that pericardial effusion was due to pericarditis and was a manifestation of chronic GVHD in this patient, and that cytotoxic lymphocytes and specific cytokines played significant roles.
DOI	10.1111/j.1600-0609.2005.00425.x
PMID	15946313