タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture.
掲載誌名	正式名：Neuroscience research ISSNコード：0168-0102
掲載区分	国外
巻・号・頁	53(2),176-82頁
著者・共著者	Makoto Yanagisawa,Kinichi Nakashima,Wataru Ochiai,Takumi Takizawa,Takao Setoguchi,Atsumi Uemura,Makiko Takizawa,Ikuo Nobuhisa,Tetsuya Taga
発行年月	2005/10
概要	Mammalian cells that have been committed to a certain cell lineage cannot be directed to other lineages. However, some astrocytes in the mammalian brains have been reported to represent plasticity to redirect to other cell lineages. We found that mouse hippocampal astrocytes cultured in aggregate forms of "astrosphere", redirected to MAP2-positive immature neurons. In astrospheres, basic HLH factors positively regulating neuronal differentiation were up-regulated and Id3 inhibiting basic HLH factors was down-regulated. Ectopic Id3 induction repressed redirection of astrocytes to a neuronal lineage, suggesting that astrosphere formation induced plasticity of astrocytes by changing the gene expression patterns.
PMID	16112216