タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	日本語
査読の有無	査読あり
表題	[Successful treatment with dasatinib for polycythemia vera patient emerging BCR-ABL positive clone during 13 years of treatment].
掲載誌名	正式名：[Rinsho ketsueki] The Japanese journal of clinical hematology ISSNコード：0485-1439
掲載区分	国内
巻・号・頁	55(6),687-91頁
著者・共著者	Makiko Takizawa,Akihiko Yokohama,Tomomi Sekigami,Hiromi Koiso,Takuma Ishizaki,Takeki Mitsui,Yoshiyuki Ogawa,Takayuki Saitoh,Hiroshi Handa,Norifumi Tsukamoto,Hirokazu Murakami,Yoshihisa Nojima
発行年月	2014/06
概要	Herein, we report a patient with polycythemia vera (PV) who exhibited Philadelphia chromosome (Ph) positive CML-like clinical features after 13 years of hydroxycarbamide administration and successful treatment with a tyrosine kinase inhibitor (TKI). She was 64 years old when initially diagnosed with PV and was confirmed to be negative for BCR-ABL translocation. Thirteen years later, with increasing white blood cell and platelet counts, a BCR-ABL positive clone emerged and the JAK2V617F mutation disappeared. After TKI treatment, the BCR-ABL copy number decreased and the JAK2V617F mutation was again detected. Furthermore, MPN clinical features were observed. This case provides insights into the clonal divergence and growth advantage of the Ph positive clone over the MPN clone. Whether JAK2V617F is an MPN initiating event or a secondary mutation has been a point of discussion for the past several years. This issue is also considered in the present report.
PMID	24975338