タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	日本語
査読の有無	査読あり
表題	正常圧水頭症で発症した軟髄膜原発B細胞性リンパ腫
掲載誌名	正式名：臨床血液
掲載区分	国内
巻・号・頁	56(12),2441-6頁
著者・共著者	石埼 卓馬,三井 健揮,内山 由理,小川 孔幸,小磯 博美,滝沢 牧子,横濱 章彦,斉藤 貴之,半田 寛,塚本 憲史,村上 博和,野島 美久
発行年月	2015/12
概要	An 80-year-old man, presenting with gait disturbance and memory loss, had findings of normal pressure hydrocephalus. Primary leptomeningeal lymphoma (PLML) was diagnosed based on cytology and flow cytometry of cerebrospinal fluid obtained by examination. Gadolinium-enhanced MRI showed enhancement of the brain and spinal cord but FDG-PET/CT revealed no lymph node swelling. With intrathecal chemotherapy, meningeal lesions disappeared and the gait disturbance and memory loss improved. However, the disease recurred three months later, manifesting as left facial nerve palsy, but the symptoms disappeared in response to intrathecal chemotherapy and systemic rituximab administration. Although a tumor lesion in the spinal canal was suggested by MRI examination, the patient has maintained a good clinical course for four years with intrathecal chemotherapy every three months. PLML is a very rare disease and its diagnosis is difficult. Repeated intrathecal chemotherapy appeared to be effective against PLML in this case.
DOI	10.11406/rinketsu.56.2441
PMID	26725352