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タキザワ マキコ
TAKIZAWA Makiko
滝沢 牧子 所属 埼玉医科大学 医学部 総合医療センター 医療安全管理学 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 日本語 |
| 査読の有無 | 査読あり |
| 表題 | Efficacy and safety of intermediate dose etoposide for mobilization of peripheral blood stem cells in hematopoietic tumors |
| 掲載誌名 | 正式名：Kitakanto Medical Journal ISSNコード：1343-2826 |
| 出版社 | Kitakanto Medical Society |
| 巻・号・頁 | 68(1),43-47頁 |
| 著者・共著者 | Takuma Ishizaki,Akihiko Yokohama,Hiroaki Shimizu,Kunio Yanagisawa,Yoshiyuki Ogawa,Takeki Mitsui,Hiromi Koiso,Makiko Takizawa,Takayuki Saitoh,Norifumi Tsukamoto,Hirokazu Murakami,Hiroshi Handa |
| 発行年月 | 2018 |
| 概要 | Autologous peripheral blood stem cell (PBSC) transplantation is a standard treatment for the recurrent refractory malignant lymphoma and symptomatic multiple myeloma in young patients. For faster engraftment after transplantation, 2.0 ×106 /kg of CD34 positive cells are required and research is ongoing regarding methods to improve the yield of PBSC collection. We investigated the efficacy and safety of chemomobilization by the intermediate dose etoposide (VP-16 350mg/m2 on days 1-4). We reviewed 19 patients with malignant lymphoma and multiple myeloma who underwent this regimen as mobilization in our institute from December 2000 to March 2015. In 15 of 19 cases (79%), stem cells were collected successfully. The median period of white blood cell count below 1,000 cells or lower was 5 days (3 days to 7 days). Though body temperature was higher than 37.5°C in 9 of 13 patients, one of whom developed bacteremia, antibiotic therapy was effective in all cases. As for non-hematological grade ≥ 3 adverse events, oral mucositis was observed in one case. Intermediate dose etoposide regimen is a safe and efficient mobilization regimen for PBSC collection. |
| DOI | 10.2974/kmj.68.43 |