タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Clinical management and outcomes of completely resected stage I follicular lymphoma.
掲載誌名	正式名：Journal of clinical and experimental hematopathology : JCEH
掲載区分	国内
巻・号・頁	58(1),10-16頁
著者・共著者	Akihiko Yokohama,Yoko Hashimoto,Makiko Takizawa,Hiroaki Shimizu,Yuri Miyazawa,Akio Saitoh,Kohtaro Toyama,Takuma Ishizaki,Takeki Mitsui,Takayuki Saitoh,Kayoko Murayama,Morio Matsumoto,Morio Sawamura,Hirokazu Murakami,Junko Hirato,Masaru Kojima,Yoshihisa Nojima,Hiroshi Handa,Norifumi Tsukamoto
発行年月	2018/03/16
概要	Recent studies have revealed the clinical and biological features of stage I follicular lymphoma (FL), but information about patients with stage I FL who underwent total resection after tissue biopsy is limited. Among 305 FL patients diagnosed between 2001 and 2013, clinical stage I disease was observed in 36 patients. Of these, 18 patients underwent total resection after diagnostic tissue biopsy. We used 18F-fluorodeoxyglucose positron emission CT for staging assessment in 13 of 18 patients (72.2%). The median age was 56.5 years. Six patients (33.3%) were male. The soluble interleukin-2 receptor alpha concentration was significantly lower than in patients with residual disease. Among these 18 patients, 7 patients (38.9%) were treated with a "watch-and-wait" (WW) policy, 7 (38.9%) were treated with involved-field irradiation, and 4 (22.2%) received systemic chemotherapy. Patients with resected disease were treated with significantly different strategies from those with residual disease (p = 0.0026). Five patients experienced relapse during follow-up (median follow-up: 48.2 months). All relapses were distant from the primary site, irrespective of treatment strategy. Among all stage I patients, disease resection was not a significant factor for survival (p = 0.9294). Collectively, the choice of treatment strategy was significantly influenced by patient status. Resection status was not significantly associated with survival after several treatment strategies.
DOI	10.3960/jslrt.17031
PMID	29415976