タキザワ　マキコ   TAKIZAWA Makiko   滝沢　牧子    所属   埼玉医科大学  医学部 総合医療センター　医療安全管理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Association between OGG1 S326C CC genotype and elevated relapse risk in acute myeloid leukemia.
掲載誌名	正式名：International journal of hematology
掲載区分	国内
巻・号・頁	108(3),246-253頁
著者・共著者	Nanami Gotoh,Takayuki Saitoh,Noriyuki Takahashi,Tetsuhiro Kasamatsu,Yusuke Minato,Alkebsi Lobna,Tsukasa Oda,Takumi Hoshino,Toru Sakura,Hiroaki Shimizu,Makiko Takizawa,Hiroshi Handa,Akihiko Yokohama,Norifumi Tsukamoto,Hirokazu Murakami
発行年月	2018/09
概要	Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the present study was to investigate the relationship between BER functional polymorphisms and AML relapse. We focused on five major polymorphisms: OGG1 S326C, MUTYH Q324H, APE1 D148E, XRCC1 R194W, and XRCC1 R399Q. Ninety-four adults with AML who achieved first complete remission were recruited. Genotyping was performed with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The OGG1 S326C CC genotype (associated with lower OGG1 activity) was observed more frequently in patients with AML relapse [28.9 vs. 8.9%, odds ratio (OR) = 4.10, 95% confidence interval (CI) = 1.35-12.70, P = 0.01]. Patients with the CC genotype exhibited shorter relapse-free survival (RFS). Moreover, the TCGA database suggested that low OGG1 expression in AML cells is associated with a higher frequency of mutations. The present findings suggest that the OGG1 S326C polymorphism increased the probability of AML relapse and may be useful as a prognostic factor for AML relapse risk.
DOI	10.1007/s12185-018-2464-9
PMID	29737460