オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection.
掲載誌名	正式名：Analytical chemistry ISSNコード：0003-2700
掲載区分	国外
巻・号・頁	79(22),8608-15頁
著者・共著者	Akane Suzuki,Tribidasari A Ivandini,Kenji Yoshimi,Akira Fujishima,Genko Oyama,Taizo Nakazato,Nobutaka Hattori,Shigeru Kitazawa,Yasuaki Einaga
発行年月	2007/11/15
概要	Highly boron-doped diamond (BDD) was deposited on chemically etched micrometer-sized tungsten wires using microwave plasma assisted chemical vapor deposition (MPCVD), and these were used to fabricate BDD microelectrodes. BDD microelectrodes with very small diameter (about 5 microm) and 250 microm in length could be made successfully. In addition to the unique properties of BDD electrodes, such as a very low background current, high stability, and selective oxidation of dopamine (DA) in the presence of ascorbic acid (AA), other superior properties of the microelectrodes, including a constant current response, an increase in the mass transport, and the ability for use in high resistance media were also shown. An application study was conducted for in vivo detection of DA in mouse brain, where the BDD microelectrode was inserted into the corpus striatum of the mouse brain. A clear signal current response following medial forebrain bundle (MFB) stimulation could be obtained with high sensitivity. Excellent stability was achieved, indicating that the BDD microelectrodes are very promising for future in vivo electroanalysis.
PMID	17918970