オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Subsecond reward-related dopamine release in the mouse dorsal striatum.
掲載誌名	正式名：Neuroscience research ISSNコード：0168-0102
掲載区分	国外
巻・号・頁	63(4),267-72頁
著者・共著者	Shihoko Natori,Kenji Yoshimi,Toshimitsu Takahashi,Maki Kagohashi,Genko Oyama,Yasushi Shimo,Nobutaka Hattori,Shigeru Kitazawa
発行年月	2009/04
概要	Reward presentation is known to induce transient bursts of midbrain dopamine neurons in monkeys and rats, and the reward-induced dopamine overflow has been detected in the rat ventral striatum. To detect reward-related dopamine release in the dorsal striatum of behaving mice (C57BL/6), we used voltammetry with carbon-fiber microelectrodes implanted into the dorsal striatum. Dopamine signals increased transiently after food delivery with a peak at 0.6 s after the delivery onset. The success in detecting transient reward-response of dopamine in behaving mice opens a wide range of application to studies in mutant mice.
PMID	19367786