オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Impaired in vivo dopamine release in parkin knockout mice.
掲載誌名	正式名：Brain research
掲載区分	国外
巻・号・頁	1352,214-22頁
著者・共著者	Genko Oyama,Kenji Yoshimi,Shihoko Natori,Yoko Chikaoka,Yong-Ri Ren,Manabu Funayama,Yasushi Shimo,Ryosuke Takahashi,Taizo Nakazato,Shigeru Kitazawa,Nobutaka Hattori
発行年月	2010/09/17
概要	parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellular dopamine (DA) overflow in the striatum with in vivo voltammetry. The amplitude of evoked DA overflow was low in PKO mice. The half-life time of evoked DA overflow was long in PKO mice suggesting lower release and uptake of dopamine. Facilitation of DA overflow by repetitive stimulation enhanced in the older PKO mice. Decreased dopamine release and uptake in young PKO mice suggest early pre-symptomatic changes in dopamine neurotransmission, while the enhanced facilitation in the older PKO mice may reflect a compensatory adaptation in dopamine function during the late pre-symptomatic phase of Parkinson's disease. Our results showed parkin deficiency may affect DA release in PKO mice, although it does not cause massive nigral degeneration or parkinsonian symptoms as in humans.
DOI	10.1016/j.brainres.2010.06.065
PMID	20620130