オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Pre- and post- GPi DBS neuropsychological profiles in a case of X-linked dystonia-Parkinsonism.
掲載誌名	正式名：The Clinical neuropsychologist
掲載区分	国外
巻・号・頁	25(1),141-59頁
著者・共著者	Nobuko Kemmotsu,Catherine C Price,Genko Oyama,Michael S Okun,Kelly D Foote,Laura L S Howe,Dawn Bowers
発行年月	2011/01
概要	We present the pre to post bilateral globus pallidus interna (GPi) deep brain stimulation neuropsychological profiles of a 69-year-old patient with a 12-year history of X-linked dystonia-Parkinsonism (XDP). Pre-operative cognitive function was impaired in almost all domains and this impaired performance was not dependent on his medications. Following DBS, changes in neuropsychological functioning were examined using Reliable Change Indices and standardized z-score comparisons. Results showed reductions in processing speed in the context of stable performance in language and visuospatial domains. Post-operative improvements occurred on a cognitive screening measure, verbal memory, and a test of problem-solving skills. This is the first report on an individual with XDP who was cognitively impaired, but had good outcome following GPi bilateral stimulation to treat debilitating motor symptoms. The possible mechanisms for his stable cognitive performance include the target of his DBS, reduced medication dosage, and improvement in dystonia that may in turn have reduced patient's pain.
DOI	10.1080/13854046.2010.532812
PMID	21253963