オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Paroxysmal Kinesigenic Dyskinesia-like Symptoms in a Patient with Tourette Syndrome.
掲載誌名	正式名：Tremor and other hyperkinetic movements (New York, N.Y.)
掲載区分	国外
巻・号・頁	1
著者・共著者	Genko Oyama,Michael S Okun,Tetsuo Ashizawa,Irene A Malaty
発行年月	2011
概要	BACKGROUND: Paroxysmal kinesigenic dyskinesia (PKD) is characterized by episodic dystonia or choreiform movements provoked by sudden voluntary movement. PKD is not commonly reported in Tourette syndrome (TS). We describe a unique case of TS with PKD-like episodic dyskinesia that responded to carbamazepine. CASE REPORT: A 36-year-old male with long-standing TS developed paroxysmal "cramping". Attacks were provoked by quick, sudden arm movements, which induced dystonic cramping, or by reaching overhead, which caused painful contraction of truncal muscles. The spells typically lasted 5-20 seconds and occurred multiple times daily. The patient's mother suffered from intermittent dystonic toe curling. In view of the similarity of symptoms to PKD, carbamazepine was prescribed at 400 mg daily. The symptoms resolved completely. Inadvertent discontinuation led to relapse, and resumption led to recapture of benefit. DISCUSSION: This case demonstrates the possibility that PKD-like symptoms may co-occur with TS and may be responsive to carbamazepine.
DOI	10.7916/D8XG9PWK
PMID	23440654