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オオヤマ ゲンコウ
OYAMA Genko
大山 彦光 所属 埼玉医科大学 医学部 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease? |
| 掲載誌名 | 正式名：The Journal of neuropsychiatry and clinical neurosciences |
| 掲載区分 | 国外 |
| 巻・号・頁 | 24(3),326-30頁 |
| 著者・共著者 | Laura B Zahodne,Oscar Bernal-Pacheco,Dawn Bowers,Herbert Ward,Genko Oyama,Natlada Limotai,Frances Velez-Lago,Ramon L Rodriguez,Irene Malaty,Nikolaus R McFarland,Michael S Okun |
| 発行年月 | 2012 |
| 概要 | Apathy is a common neuropsychiatric feature of Parkinson's disease (PD), but little is known of relationships between apathy and specific medications in PD. Following a retrospective database and chart review of 181 Parkinson's patients, relationships between Apathy Scale scores and use of psychotropic and antiparkinsonian medications were examined with multiple regression. Controlling for age, sex, education, and depression, the use of selective serotonin reuptake inhibitors (SSRIs), but not other antidepressants, was associated with greater apathy. Use of monoamine oxidase B inhibitors was associated with less apathy. Longitudinal studies are needed to evaluate a potential SSRI-induced apathy syndrome in PD. |
| DOI | 10.1176/appi.neuropsych.11090210 |
| PMID | 23037646 |