オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Addiction-like manifestations and Parkinson's disease: a large single center 9-year experience.
掲載誌名	正式名：The International journal of neuroscience
掲載区分	国外
巻・号・頁	122(3),145-53頁
著者・共著者	Natlada Limotai,Genko Oyama,Criscely Go,Oscar Bernal,Tiara Ong,Sarah J Moum,Roongroj Bhidayasiri,Kelly D Foote,Dawn Bowers,Herbert Ward,Michael S Okun
発行年月	2012/03
概要	OBJECTIVE: Characterize potential risk factors and the relationship of dopamine agonist (DA) withdrawal syndrome (DAWS), dopamine dysregulation syndrome (DDS), and impulse control disorders (ICDs) in Parkinson's disease (PD). METHODS: A retrospective chart review categorized cases into three groups: DAWS, DDS, and ICDs. RESULTS: A total of 1,040 subjects met inclusion criteria. There were 332 subjects with a history of tapering DAs and 26 (7.8%) developed DAWS. Fourteen (1.3%) and 89 (8.6%) met the criteria for both DDS and ICD. Subjects with DAWS, DDS, and ICDs had a higher baseline dose of DA, levodopa, and total dopaminergic medication (p < .05), compared to those without the three conditions. DDS was found to be related to the DAWS group (p < .001). When comparing to the PD population without DDS, younger age at onset of PD (p = .027), presence of DAWS (p < .001), ICDs (p = .003), and punding (p = .042) were all correlated with the DDS group, while male sex (p = .045), younger age at onset of PD (p < .001), presence of DAWS (p < .001), and presence of DDS (p = .001) and punding (p < .001) were related to the ICD group. CONCLUSIONS: There was a strong relationship between DAWS, DDS, and ICD in this large PD cohort. Dopaminergic therapy in a subset of PD patients was strongly associated with addiction-like behavioral issues.
DOI	10.3109/00207454.2011.633722
PMID	22023411