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オオヤマ ゲンコウ
OYAMA Genko
大山 彦光 所属 埼玉医科大学 医学部 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Differential and better response to deep brain stimulation of chorea compared to dystonia in Huntington's disease. |
| 掲載誌名 | 正式名：Stereotactic and functional neurosurgery |
| 掲載区分 | 国外 |
| 巻・号・頁 | 91(2),129-33頁 |
| 著者・共著者 | Frances M Velez-Lago,Amanda Thompson,Genko Oyama,Angela Hardwick,Justin M Sporrer,Pamela Zeilman,Kelly D Foote,Dawn Bowers,Herbert E Ward,Juan Sanchez-Ramos,Michael S Okun |
| 発行年月 | 2013 |
| 概要 | Huntington's disease (HD) is an autosomal dominant and progressive neurodegenerative syndrome characterized by motor, cognitive and psychiatric manifestations. Chorea and dystonia are features that may be troublesome to some patients and may potentially prove unresponsive to pharmacological treatments. There are several reports on the results of globus pallidus internus deep brain stimulation (DBS) surgery for HD. In these published cases, DBS was utilized mainly to treat disabling chorea. We report our experience with 2 HD cases treated with DBS. The cases illustrate a differential response with a better outcome in the choreic presentation compared to the dystonic presentation. Additionally, DBS worsened gait features in both cases. |
| DOI | 10.1159/000341070 |
| PMID | 23343665 |