オオヤマ ゲンコウ   OYAMA Genko
  大山 彦光
   所属   埼玉医科大学  医学部 脳神経内科
   職種   教授
論文種別 学術雑誌(原著)
言語種別 日本語
査読の有無 査読あり
表題 Update on deep brain stimulation for movement disorders
掲載誌名 正式名:Clinical Neurology
ISSNコード:0009-918X
巻・号・頁 53(11),911-914頁
著者・共著者 Atsushi Umemura,Genko Oyama,Yasushi Shimo,Nobutaka Hattori
発行年月 2013
概要 Deep brain stimulation (DBS) has been widely performed for various medically refractory movement disorders. For Parkinson disease (PD), target of DBS is subthalamic nucleus (STN) or globus pallidus internus (GPi). There are some evidences to demonstrate its effectiveness on motor function and QOL. DBS effectively improves levodopa-responsive motor symptoms, and significantly reduces dyskinesia and motor fluctuations. STN DBS particularly decreases the need for dopaminergic medication. A combination of medical treatment and DBS would provide longer relief of motor symptoms than medical treatment only. Currently new evidence supporting early introduction of DBS for better future outcome is published. DBS of Vim thalamus has been indicated for intractable tremor with various etiologies. Recently posterior subthalamic area (PSA) is introduced as an alternative target to Vim for tremor. GPi DBS is also effective treatment option for generalized dystonia.
DOI 10.5692/clinicalneurol.53.911
PMID 24291831