オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Low-frequency Versus High-frequency Subthalamic Nucleus Deep Brain Stimulation on Postural Control and Gait in Parkinson's Disease: A Quantitative Study
掲載誌名	正式名：BRAIN STIMULATION ISSNコード：1935-861X/1876-4754
出版社	ELSEVIER SCIENCE INC
巻・号・頁	8(1),64-75頁
著者・共著者	Srikant Vallabhajosula,Ihtsham U. Haq,Nelson Hwynn,Genko Oyama,Michael Okun,Mark D. Tillman,Chris J. Hass
発行年月	2015/01
概要	Background: High frequency stimulation (HFS) of the subthalamic nucleus (STN-DBS) has been shown to have little impact on postural control and gait improvements in Parkinson's disease (PD). There is a lack of consensus and quantitative evidence to suggest that stimulating STN at a lower frequency (LFS) as compared to HFS will be superior in improving symptoms.Objective/hypothesis: To determine if postural control and gait characteristics of persons with PD improve at an LFS (60 Hz) compared to HFS (> 100 Hz). We hypothesized that persons with PD would perform better on postural control and gait measures at LFS.Methods: Nineteen participants with bilateral STN-DBS underwent UPDRS, static and dynamic postural control using gait initiation, and gait evaluations in three stimulation conditions (baseline voltage stable across conditions: OFF, LFS of 60 Hz, and HFS of > 100 Hz). Additionally 10/19 participants were also stimulated at 30 Hz and 60 Hz and at higher voltages. A one-way ANOVA was performed to compare the conditions.Results: Total UPDRS-III score, step length and velocity during gait initiation, and gait speed significantly improved during 60 Hz and > 100 Hz conditions when compared to the OFF condition (P < 0.05). There were no significant differences between 60 Hz and > 100 Hz conditions. Using LFS at higher voltage showed no improvement over > 100 Hz condition.Conclusions: The positive effects of both LFS and HFS on postural control and gait were similar and clinical changes were relatively small. LFS may not help improve postural control, and gait particularly for persons with PD who do not develop gait-related disorders after HFS. (C) 2015 Elsevier Inc. All rights reserved.
DOI	10.1016/j.brs.2014.10.011