オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics.
掲載誌名	正式名：BMC neurology
掲載区分	国外
巻・号・頁	16,66-66頁
著者・共著者	Asako Yoritaka,Takashi Abe,Chigumi Ohtsuka,Tetsuya Maeda,Masaaki Hirayama,Hirohisa Watanabe,Hidemoto Saiki,Genko Oyama,Jiro Fukae,Yasushi Shimo,Taku Hatano,Sumihiro Kawajiri,Yasuyuki Okuma,Yutaka Machida,Hideto Miwa,Chikako Suzuki,Asuka Kazama,Masahiko Tomiyama,Takeshi Kihara,Motoyuki Hirasawa,Hideki Shimura,Nobutaka Hattori
発行年月	2016/05/12
概要	BACKGROUND: Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. METHODS: Changes in the total UPDRS scores from baseline to the 8(th), 24(th), 48(th), and 72(nd) weeks, and after the 8(th) week, will be evaluated. The primary endpoint of the efficacy of this treatment in PD is the change in the total UPDRS score from baseline to the 72(nd) week. The changes in UPDRS part II, UPDRS part III, each UPDRS score, PD Questionnaire-39 (PDQ-39), and the modified Hoehn and Yahr stage at these same time-points, as well as the duration until the protocol is finished because additional levodopa is required or until the disease progresses, will also be analyzed. Adverse events and screening laboratory studies will also be examined. Participants in the hydrogen water group will drink 1000 mL/day of H2 water, and those in the placebo water group will drink normal water. One-hundred-and-seventy-eight participants with PD (88 women, 90 men; mean age: 64.2 [SD 9.2] years, total UPDRS: 23.7 [11.8], with levodopa medication: 154 participants, without levodopa medication: 24 participants; daily levodopa dose: 344.1 [202.8] mg, total levodopa equivalent dose: 592.0 [317.6] mg) were enrolled in 14 hospitals and were randomized. DISCUSSION: This study will confirm whether H2 water can improve PD symptoms. TRIAL REGISTRATION: UMIN000010014 (February, 13, 2013).
DOI	10.1186/s12883-016-0589-0
PMID	27176725