オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Interleaving stimulation with a combination of bipolar and monopolar configurations for secondary failure of bilateral subthalamic stimulation in Parkinson's disease
掲載誌名	正式名：NEUROLOGY AND CLINICAL NEUROSCIENCE ISSNコード：2049-4173
出版社	JOHN WILEY & SONS INC
巻・号・頁	5(1),32-33頁
著者・共著者	Rina Tsukada,Genko Oyama,Yasushi Shimo,Satoko Sekimoto,Takayuki Jo,Asuka Nakajima,Atsushi Umemura,Hajime Arai,Nobutaka Hattori
発行年月	2017/01
概要	Current control technology using interleaving stimulation could be theoretically useful for maximizing the benefits of deep brain stimulation, but it is seldom reported. A 61-year-old man with young-onset Parkinson's disease was previously treated with bilateral subthalamic nucleus deep brain stimulation because of wearing-off and peak-dose dyskinesia; he again developed wearing-off and a gait disturbance 3 years after surgery. His deep brain stimulation was adjusted by utilizing interleaving stimulation with a combination of monopolar and bipolar configurations, because increasing stimulation with single or double monopolar stimulation, and interleaving monopolar stimulation caused pyramidal side-effects. After adjusting deep brain stimulation, his wearing-off symptoms and gait disturbance were markedly improved without any side-effects. The present case report describes the potential of interleaving stimulation with a combination of monopolar and bipolar settings for the treatment of Parkinson's disease.
DOI	10.1111/ncn3.12085