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オオヤマ ゲンコウ
OYAMA Genko
大山 彦光 所属 埼玉医科大学 医学部 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Progressive multifocal leukoencephalopathy with immune reconstitution inflammatory syndrome following treatment for granulomatosis with polyangiitis |
| 掲載誌名 | 正式名：NEUROLOGY AND CLINICAL NEUROSCIENCE ISSNコード：2049-4173 |
| 出版社 | WILEY |
| 巻・号・頁 | 6(3),83-85頁 |
| 著者・共著者 | Fuyuko Sasaki,Genko Oyama,Motoki Fujimaki,Kazumasa Yokoyama,Michihiro Ogasawara,Kazuo Nakamichi,Masayuki Saijo,Yoshinari Takasaki,Nobutaka Hattori |
| 発行年月 | 2018/05 |
| 概要 | A 56-year-old man with granulomatosis with polyangiitis (GPA) developed progressive multifocal leukoencephalopathy (PML) after a combined immune therapy with methotrexate and prednisolone. Despite negative conversion of JC virus after cessation of methotrexate treatment and tapering of prednisone, he developed amnestic aphasia, left hemispatial neglect, and left hemiplegia, which was confirmed as immune reconstitution inflammatory syndrome (IRIS) based on a rapid expansion of the lesions bilaterally with marginal gadolinium enhancement on brain magnetic resonance imaging. This case suggests that it may be important to be aware of possibility of IRIS, in cases of worsening neurological symptoms despite discontinuation of immunosuppressive treatments for GPA with PML. |
| DOI | 10.1111/ncn3.12192 |