オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Effect of subthalamic nucleus deep brain stimulation on visual scanning.
掲載誌名	正式名：Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
掲載区分	国外
巻・号・頁	129(11),2421-2432頁
著者・共著者	Shin-Ichi Tokushige,Shun-Ichi Matsuda,Genko Oyama,Yasushi Shimo,Atsushi Umemura,Takuya Sasaki,Satomi Inomata-Terada,Akihiro Yugeta,Masashi Hamada,Yoshikazu Ugawa,Shoji Tsuji,Nobutaka Hattori,Yasuo Terao
発行年月	2018/11
概要	OBJECTIVE: Deep brain stimulation (DBS) can provide insights into the workings of the basal ganglia (BG) by interfering with their function. In patients with Parkinson's disease (PD) treated with DBS of the subthalamic nucleus, we studied the effect of DBS on scanning eye movements. METHODS: In the visual memory task, subjects viewed images of various complexities for later recall. In visual search tasks, subjects looked for and fixated one odd target ring, embedded among 48 Landolt rings, which either stood out or not from the distractors. We compared the parameters of scanning saccades when DBS was on and off. RESULTS: In the visual memory task, DBS increased the amplitude of saccades scanning simple but not complex drawings. In the visual search tasks, DBS showed no effect on saccade amplitude or frequency. CONCLUSIONS: Saccades when viewing simple images were affected by DBS since they are internally guided saccades, for which the involvement of BG is large. In contrast, saccades when viewing complex images or during visual search, made with the help of visual cues in the images (externally guided saccades) and less dependent on BG, were resistant to the effect of DBS. SIGNIFICANCE: DBS affects saccades differentially depending on the task.
DOI	10.1016/j.clinph.2018.08.003
PMID	30292079