オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Free-Water Imaging in White and Gray Matter in Parkinson's Disease.
掲載誌名	正式名：Cells
掲載区分	国外
巻・号・頁	8(8)
著者・共著者	Christina Andica,Koji Kamagata,Taku Hatano,Asami Saito,Wataru Uchida,Takashi Ogawa,Haruka Takeshige-Amano,Andrew Zalesky,Akihiko Wada,Michimasa Suzuki,Akifumi Hagiwara,Ryusuke Irie,Masaaki Hori,Kanako K Kumamaru,Genko Oyama,Yashushi Shimo,Atsushi Umemura,Christos Pantelis,Nobutaka Hattori,Shigeki Aoki
発行年月	2019/08/05
概要	This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM) of patients with Parkinson's disease (PD) using free-water (FW) imaging. Analysis using tract-based spatial statistics (TBSS) of 20 patients with PD and 20 healthy individuals revealed changes in FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased FW-corrected mean, axial, and radial diffusivities (MDT, ADT, and RDT, respectively) and fractional volume of FW (FW) in somewhat more specific WM areas compared with the changes of DTI indices. The region-of-interest (ROI) analysis further supported these findings, whereby those with PD showed significantly lower FAT and higher MDT, ADT, and RDT (indices of neuronal degeneration) in anterior WM areas as well as higher FW (index of neuroinflammation) in posterior WM areas compared with the controls. Results of GM-based spatial statistics (GBSS) analysis revealed that patients with PD had significantly higher MDT, ADT, and FW than the controls, whereas ROI analysis showed significantly increased MDT and FW and a trend toward increased ADT in GM areas, corresponding to Braak stage IV. These findings support the hypothesis that neuroinflammation precedes neuronal degeneration in PD, whereas WM microstructural alterations precede changes in GM.
DOI	10.3390/cells8080839
PMID	31387313