オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Rescue Levodopa/Carbidopa Intestinal Gel for Secondary Deep Brain Stimulation Failure.
掲載誌名	正式名：Journal of movement disorders
掲載区分	国外
巻・号・頁	13(1),57-61頁
著者・共著者	Juan Miguel Pilar Bautista,Genko Oyama,Maierdanjiang Nuermaimaiti,Satoko Sekimoto,Fuyuko Sasaki,Taku Hatano,Kenya Nishioka,Masanobu Ito,Atsushi Umemura,Yuji Ishibashi,Yasushi Shimo,Nobutaka Hattori
発行年月	2020/01
概要	OBJECTIVE: The long-term efficacy of deep brain stimulation (DBS) for motor fluctuations in advanced Parkinson's disease (PD) has been well established; however, motor fluctuations may recur over time despite multiple adjustments of DBS settings and medications. METHODS: We conducted a retrospective chart review of three patients for whom levodopa-carbidopa intestinal gel (LCIG) was additionally administered as a rescue therapy for secondary DBS failure due to the recurrence of motor fluctuations. RESULTS: The three patients had advanced PD with a disease duration of 14-19 years, and had undergone DBS for motor fluctuations refractory to standard medical management. LCIG was administered to the patients because of symptom recurrence years after DBS and provided complementary effects in all patients. CONCLUSION: The cases presented here show that rescue LCIG therapy may be a complementary treatment option for patients with post-DBS advanced PD who have a recurrence of troublesome motor complications.
DOI	10.14802/jmd.19051
PMID	31986869