オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Evaluation of white matter microstructure in patients with Parkinson's disease using microscopic fractional anisotropy.
掲載誌名	正式名：Neuroradiology
掲載区分	国外
巻・号・頁	62(2),197-203頁
著者・共著者	Yutaka Ikenouchi,Koji Kamagata,Christina Andica,Taku Hatano,Takashi Ogawa,Haruka Takeshige-Amano,Kouhei Kamiya,Akihiko Wada,Michimasa Suzuki,Shohei Fujita,Akifumi Hagiwara,Ryusuke Irie,Masaaki Hori,Genko Oyama,Yashushi Shimo,Atsushi Umemura,Nobutaka Hattori,Shigeki Aoki
発行年月	2020/02
概要	PURPOSE: Micro fractional anisotropy (μFA) is more accurate than conventional fractional anisotropy (FA) for assessing microscopic tissue properties and can overcome limitations related to crossing white matter fibres. We compared μFA and FA for evaluating white matter changes in patients with Parkinson's disease (PD). METHODS: We compared FA and μFA measures between 25 patients with PD and 25 age- and gender-matched healthy controls using tract-based spatial statistics (TBSS) analysis. We also examined potential correlations between changes, revealed by conventional FA or μFA, and disease duration or Unified Parkinson's Disease Rating Scale (UPDRS)-III scores. RESULTS: Compared with healthy controls, patients with PD had significantly reduced μFA values, mainly in the anterior corona radiata (ACR). In the PD group, μFA values (primarily those from the ACR) were significantly negatively correlated with UPDRS-III motor scores. No significant changes or correlations with disease duration or UPDRS-III scores with tissue properties were detected using conventional FA. CONCLUSION: μFA can evaluate microstructural changes that occur during white matter degeneration in patients with PD and may overcome a key limitation of FA.
DOI	10.1007/s00234-019-02301-1
PMID	31680195