オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis
掲載誌名	正式名：Scientific Reports ISSNコード：2045-2322
掲載区分	国外
出版社	Springer Science and Business Media LLC
巻・号・頁	12(1),18348-18348頁
著者・共著者	Ken Nagino,Jaemyoung Sung,Genko Oyama,Motoshi Hayano,Nobutaka Hattori,Yuichi Okumura,Kenta Fujio,Yasutsugu Akasaki,Tianxiang Huang,Akie Midorikawa-Inomata,Keiichi Fujimoto,Atsuko Eguchi,Shokirova Hurramhon,Maria Miura,Mizu Ohno,Kunihiko Hirosawa,Yuki Morooka,Akira Murakami,Hiroyuki Kobayashi,Takenori Inomata
発行年月	2022/11/01
概要	Abstract We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian–Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.
DOI	10.1038/s41598-022-22037-y
PMID	36319814
PermalinkURL	https://www.nature.com/articles/s41598-022-22037-y.pdf
researchmap用URL	https://www.nature.com/articles/s41598-022-22037-y