オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Impaired virtual space-tilting perception in Parkinson's disease with Pisa syndrome
掲載誌名	正式名：Parkinsonism & Related Disorders ISSNコード：1353-8020
掲載区分	国外
出版社	Elsevier BV
巻・号・頁	104,30-34頁
著者・共著者	Fuyuko Sasaki,Genko Oyama,Yoshihiko Hirozane,Ryo Yamashita,Satoko Sekimoto,Nobutaka Hattori
発行年月	2022/11
概要	INTRODUCTION: The mechanism of Pisa syndrome in Parkinson's disease (PD) is unclear. We aimed to analyze the spatial perception of patients with PD with Pisa syndrome using virtual reality. METHODS: In total, 16 patients with Pisa syndrome, 16 age-matched patients without Pisa syndrome, and 16 age-matched controls were included. They viewed the virtual room gradually tilting to different 8 directions randomized across trials. The 75% discrimination threshold angle and the mean tilting discrimination angle for each direction were evaluated. Participants' lateral trunk deviation was measured using Kinect. Neuropsychological status was evaluated, using the Mini-Mental Status Examination (MMSE), the Japanese version of the Montreal-Cognitive Assessment, Frontal Assessment Battery, and the color-word interference task of the Stroop test. Visuospatial abilities were assessed using Benton Judgement of Line Orientation, and vestibular function was evaluated using Subjective Visual Vertical (SVV). RESULTS: The 75% discrimination threshold in the tilting discrimination angle was larger in all directions for those in the Pisa syndrome group compared to patients in the without Pisa syndrome group and those in the control group. There were significant differences between the three groups for Front-Right, Right, and Back. Patients with Pisa syndrome showed a significantly worse performance in these tests compared with controls and tended to have worse SVV performance compared with patients without Pisa syndrome. CONCLUSION: The present findings support the hypothesis of visuo-spatial disability and/or attentional impairment in patients with Pisa syndrome.
DOI	10.1016/j.parkreldis.2022.09.002
PMID	36208613