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オオヤマ ゲンコウ
OYAMA Genko
大山 彦光 所属 埼玉医科大学 医学部 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Analytical and clinical validity of wearable, multi-sensor technology for assessment of motor function in patients with Parkinson's disease in Japan. |
| 掲載誌名 | 正式名：Scientific reports |
| 掲載区分 | 国外 |
| 巻・号・頁 | 13(1),3600-3600頁 |
| 著者・共著者 | Genko Oyama,Maximilien Burq,Taku Hatano,William J Marks Jr,Ritu Kapur,Jovelle Fernandez,Keita Fujikawa,Yoshihiko Furusawa,Keisuke Nakatome,Erin Rainaldi,Chen Chen,King Chung Ho,Takashi Ogawa,Hikaru Kamo,Yutaka Oji,Haruka Takeshige-Amano,Daisuke Taniguchi,Ryota Nakamura,Fuyuko Sasaki,Shinichi Ueno,Kenta Shiina,Anri Hattori,Noriko Nishikawa,Mayu Ishiguro,Shinji Saiki,Ayako Hayashi,Masatoshi Motohashi,Nobutaka Hattori |
| 発行年月 | 2023/03/14 |
| 概要 | Continuous, objective monitoring of motor signs and symptoms may help improve tracking of disease progression and treatment response in Parkinson's disease (PD). This study assessed the analytical and clinical validity of multi-sensor smartwatch measurements in hospitalized and home-based settings (96 patients with PD; mean wear time 19 h/day) using a twice-daily virtual motor examination (VME) at times representing medication OFF/ON states. Digital measurement performance was better during inpatient clinical assessments for composite V-scores than single-sensor-derived features for bradykinesia (Spearman |r|= 0.63, reliability = 0.72), tremor (|r|= 0.41, reliability = 0.65), and overall motor features (|r|= 0.70, reliability = 0.67). Composite levodopa effect sizes during hospitalization were 0.51-1.44 for clinical assessments and 0.56-1.37 for VMEs. Reliability of digital measurements during home-based VMEs was 0.62-0.80 for scores derived from weekly averages and 0.24-0.66 for daily measurements. These results show that unsupervised digital measurements of motor features with wrist-worn sensors are sensitive to medication state and are reliable in naturalistic settings.Trial Registration: Japan Pharmaceutical Information Center Clinical Trials Information (JAPIC-CTI): JapicCTI-194825; Registered June 25, 2019. |
| DOI | 10.1038/s41598-023-29382-6 |
| PMID | 36918552 |