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オオヤマ ゲンコウ
OYAMA Genko
大山 彦光 所属 埼玉医科大学 医学部 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Three-dimensional gait analysis of the effect of directional steering on gait in patients with Parkinson's disease. |
| 掲載誌名 | 正式名：Parkinsonism & related disorders |
| 掲載区分 | 国外 |
| 巻・号・頁 | 114,105770-105770頁 |
| 著者・共著者 | Satoko Sekimoto,Genko Oyama,Kotatsu Bito,Masaru Tsuchiya,Sho Kikuchi,Baku Takimoto,Toshiki Ichihashi,Juan Miguel P Bautista,Maierdanjiang Nuermaimaiti,Fuyuko Sasaki,Ryota Nakamura,Hirokazu Iwamuro,Masanobu Ito,Atsushi Umemura,Nobutaka Hattori |
| 発行年月 | 2023/09 |
| 概要 | INTRODUCTION: Deep Brain Stimulation (DBS) is an option to treat advanced Parkinson's Disease (PD), but can cause gait disturbance due to stimulation side efffects. This study aims to evaluate the objective effect of directional current steering by DBS on gait performance in PD, utilizing a three-dimensional gait analysis system. METHODS: Eleven patients diagnosed with PD and were implanted with directional lead were recruited. The direction of the pyramidal tract (identified by the directional mode screening) was set as 0°. Patients performed the six-meter-walk test and the time up-and-go (TUG) test while an analysis system recorded gait parameters utilizing a three-dimensional motion capture camera. The gait parameters were measured for the baseline, the directional steering at eight angles (0°, 45°, 90°, 135°, 180°, 225°, 270°, and 315°), and the conventional ring mode with 1, 2, and 3 mA. Pulse width and frequency were fixed. Placebo stimulation (0 mA) was used for a control. RESULTS: Eleven patients completed the study. No significant difference were observed between gait parameters during the directional, baseline, placebo, or ring modes during the six-meter-walk test (p > 0.05). During the TUG test, stride length was significantly different between 0° and other directions (p < 0.001), but no significant differences were observed for the other gait parameters. Stride width was non-significantly narrower in the direction of 0°. CONCLUSION: Controlling stimulation using directional steering may improve gait in patients with PD, while avoiding pyramidal side effects. |
| DOI | 10.1016/j.parkreldis.2023.105770 |
| PMID | 37499354 |