オオヤマ　ゲンコウ   OYAMA Genko   大山　彦光    所属   埼玉医科大学  医学部 脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	A proof of concept: digital diary using 24-hour monitoring using wearable device for patients with Parkinson's disease in nursing homes.
掲載誌名	正式名：Frontiers in neurology
掲載区分	国外
巻・号・頁	15,1356042-1356042頁
著者・共著者	Hikaru Kamo,Genko Oyama,Yui Yamasaki,Tomohiro Nagayama,Ryotatsu Nawashiro,Nobutaka Hattori
発行年月	2024
概要	INTRODUCTION: In the advanced stages of Parkinson's disease (PD), motor complications such as wearing-off and dyskinesia are problematic and vary daily. These symptoms need to be monitored precisely to provide adequate care for patients with advanced PD. METHODS: This study used wearable devices to explore biomarkers for motor complications by measuring multiple biomarkers in patients with PD residing in facilities and combining them with lifestyle and clinical assessments. Data on the pulse rate and activity index (metabolic equivalents) were collected from 12 patients over 30 days. RESULTS: The pulse rate and activity index during the off- and on-periods and dyskinesia were analyzed for two participants; the pulse rate and activity index did not show any particular trend in each participant; however, the pulse rate/activity index was significantly greater in the off-state compared to that in the dyskinesia and on-states, and this index in the dyskinesia state was significantly greater than that in the on-state in both participants. CONCLUSION: These results suggest the pulse rate and activity index combination would be a useful indicator of wearing-off and dyskinesia and that biometric information from wearable devices may function as a digital diary. Accumulating more cases and collecting additional data are necessary to verify our findings.
DOI	10.3389/fneur.2024.1356042
PMID	38660090