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オオヤマ ゲンコウ
OYAMA Genko
大山 彦光 所属 埼玉医科大学 医学部 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease. |
| 掲載誌名 | 正式名：Journal of the neurological sciences |
| 掲載区分 | 国外 |
| 巻・号・頁 | 457,122883-122883頁 |
| 著者・共著者 | Haruka Takeshige-Amano,Taku Hatano,Koji Kamagata,Christina Andica,Takashi Ogawa,Atsuhiko Shindo,Wataru Uchida,Wataru Sako,Shinji Saiki,Yasushi Shimo,Genko Oyama,Atsushi Umemura,Masanobu Ito,Masaaki Hori,Shigeki Aoki,Nobutaka Hattori |
| 発行年月 | 2024/02/15 |
| 概要 | INTRODUCTION: Monoamine oxidase type B inhibitors, including selegiline, are established as anti-Parkinsonian Drugs. Inhibition of monoamine oxidase type B enzymes might suppress the inflammation because of inhibition to generate reactive oxygen species. However, its effect on brain microstructure remains unclear. The aim of this study is to elucidate white matter and substantia nigra (SN) microstructural differences between Patients with Parkinson's disease with and without selegiline treatment by two independently recruited cohorts. METHODS: Diffusion tensor imaging and free water imaging indices of WM and SN were compared among 22/15 Patients with Parkinson's disease with selegiline (PDselegiline(+)), 33/23 Patients with Parkinson's disease without selegiline (PDselegiline(-)), and 25/20 controls, in the first/second cohorts. Two cohorts were analyzed with different MRI protocols. RESULTS: Diffusion tensor imaging and free-water indices of major white matter tracts were significantly differed between the PDselegiline(-) and controls in both cohorts, although not between the PDselegiline(+) and controls except for restricted areas. Compared with the PDselegiline(+), free-water was significantly higher in the PDselegiline(-) in the inferior fronto-occipital fasciculus, superior longitudinal fasciculus, and superior and posterior corona radiata (first cohort) and the forceps major and splenium of the corpus callosum (second cohort). There were no significant differences in free-water of anterior or posterior substantia nigra between PDselegiline(+) and PDselegiline(-). CONCLUSIONS: Selegiline treatment might reduce the white matter microstructural abnormalities detected by free-water imaging in Parkinson's disease. |
| DOI | 10.1016/j.jns.2024.122883 |
| PMID | 38246127 |