スダ　サトシ   SUDA Satoshi   須田　智    所属   埼玉医科大学  医学部 国際医療センター　神経内科・脳卒中内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Effect of edaravone, a free radical scavenger, on ischemic cerebral edema assessed by magnetic resonance imaging
掲載誌名	正式名：NEUROLOGIA MEDICO-CHIRURGICA ISSNコード：0470-8105
出版社	JAPAN NEUROSURGICAL SOC
巻・号・頁	47(5),197-201頁
著者・共著者	Satoshi Suda,Hironaka Igarashi,Yasushi Arai,Jyun Andou,Tetsuro Chishiki,Yasuo Katayama
発行年月	2007/05
概要	The anti-edema effect of edaravone, a free radical scavenger, was evaluated by magnetic resonance imaging in six patients with extensive hemispheric ischemic stroke. T-2 relaxation time in the infarct core, the boundary zone of the infarct, and the noninfarcted hemisphere were calculated, and T, mapping was performed before and after edaravone administration. Edaravone administration significantly decreased the mean T, relaxation time in the boundary zone of the infarct from 121.5 +/- 9.2 (mean +/- standard deviation) to 114.5 +/- 9.9 msec (p = 0.008), but not in the core from 142.3 +/- 13.4 to 142.2 +/- 18.5 msec (p = 0.97) or the noninfarcted hemisphere from 93.0 +/- 3.7 to 93.1 +/- 3.8 msec (p = 0.91). The T-2 subtraction map clearly demonstrated shortened T-2 relaxation time in the boundary zone of the infarct. The present results indicate that edaravone can salvage the boundary zone of the infarct and is a useful cytoprotective anti-edema agent.