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スダ サトシ
SUDA Satoshi
須田 智 所属 埼玉医科大学 医学部 国際医療センター 神経内科・脳卒中内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Low Free Triiodothyronine at Admission Predicts Poststroke Infection |
| 掲載誌名 | 正式名：Journal of Stroke and Cerebrovascular Diseases ISSNコード：1532-8511 |
| 出版社 | W.B. Saunders |
| 巻・号・頁 | 27(2),397-403頁 |
| 著者・共著者 | Satoshi Suda,Junya Aoki,Takashi Shimoyama,Kentaro Suzuki,Yuki Sakamoto,Takehiro Katano,Seiji Okubo,Chikako Nito,Yasuhiro Nishiyama,Masahiro Mishina,Kazumi Kimura |
| 発行年月 | 2018/02/01 |
| 概要 | Background: Poststroke infection (PSI) is common and is usually associated with a severe prognosis. We investigated the association between PSI and thyroid hormones, which are critical to immune regulation, in patients with acute stroke. Methods: We retrospectively enrolled 520 consecutive patients with acute ischemic stroke (326 men age, 71.9 ± 13.2 years) admitted to our department between September 2014 and June 2016. The impact of serum thyroid hormone levels measured at admission (thyroid-stimulating hormone [TSH], free triiodothyronine [FT3], and free thyroxine [FT4]) on the PSI was evaluated using multivariate logistic regression analysis. Results: We diagnosed 107 patients (20.6% pneumonia, 65 urinary tract infection, 19 others, 23) with PSIs. While age (P < .001), body mass index (P =.0012), preadmission modified Rankin scale score (P =.0001), National Institutes of Health Stroke Scale score on admission (P < .001), admission FT3 level (P < .001), atrial fibrillation (P < .001), and ischemic heart disease (P =.0451) were significantly associated with PSI, we found no relationship among TSH levels, FT4 levels, and PSI occurrence. After multivariate adjustment, patients with PSIs were more frequently in the Q1 quartile (≤2.25 pg/mL) than in the Q2 (2.26-2.55 pg/mL P =.0251), Q3 (2.56-2.89 pg/mL P =.0007), or Q4 (≥2.90 pg/mL P =.0010) quartiles of FT3 levels. Moreover, low FT3 levels (< 2.29 pg/mL) were independently associated with PSI occurrence (P =.0013). Conclusions: Low FT3 levels at admission are independently associated with PSI occurrence. |
| DOI | 10.1016/j.jstrokecerebrovasdis.2017.09.012 |
| PMID | 29031498 |