スダ　サトシ   SUDA Satoshi   須田　智    所属   埼玉医科大学  医学部 国際医療センター　神経内科・脳卒中内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Risk factors, etiology, and outcome of ischemic stroke in young adults: A Japanese multicenter prospective study
掲載誌名	正式名：Journal of the Neurological Sciences ISSNコード：0022-510X
掲載区分	国外
出版社	Elsevier BV
巻・号・頁	417,117068-117068頁
著者・共著者	Yu Kono,Yuka Terasawa,Kenichiro Sakai,Yasuyuki Iguchi,Yasuhiro Nishiyama,Chikako Nito,Satoshi Suda,Kazumi Kimura,Takao Kanzawa,Ichiro Imafuku,Takahiro Nakayama,Masayuki Ueda,Takeshi Iwanaga,Tomoyuki Kono,Kazuo Yamashiro,Ryota Tanaka,Seiji Okubo,Makoto Nakajima,Nobuhito Nakajima,Masahiro Mishina,Hiroshi Yaguchi,Hisayoshi Oka,Masahiko Suzuki,Masato Osaki,Nobuyuki Kaneko,Kazuo Kitagawa,Sadahisa Okamoto,Koichi Nomura,Mineo Yamazaki,Takehiko Nagao,Yoshitaka Murakami
発行年月	2020/10
概要	PURPOSE: This study aimed to evaluate the risk factors, etiology, and outcomes of ischemic stroke (IS) in Japanese young adults. METHODS: This was a prospective multicenter study. We enrolled patients aged 16 to 55 years with IS within seven days of the onset of symptoms. We assessed the demographic data, risk factors, stroke etiology, and outcome at discharge. The clinical characteristics were compared between sexes and among age groups. RESULTS: We prospectively enrolled 519 patients (median age, 48 years: 139 females). The mean National Institute of Health Stroke Scale score was 3.6 ± 0.2. The most common risk factors were hypertension (HT) (55%), dyslipidemia (DL) (47%), and current smoking (42%). Body mass index, incidence of current smoking, and heavy alcohol consumption were higher in males. The prevalence of current smoking, HT, DL, and diabetes mellitus increased with aging. The most common etiologic subgroup of IS was small vessel disease (145/510, 28%). Intracranial arterial dissection (IAD) was the most common among the other determined causes (56/115, 49%). The outcome at discharge was relatively good (mRS 0-1, 71.7%); however, poor outcome (mRS ≥ 4) was observed at an incidence of 9.5%. CONCLUSIONS: Most young adults with IS had modifiable risk factors, of which prevalence increased with age. This emphasizes lifestyle improvement to prevent IS in the young population. Furthermore, we indicated that the incidence rate of IAD was high among the other determined causes.
DOI	10.1016/j.jns.2020.117068
PMID	32745720