ヨゴサワ　シンゴ   YOGOSAWA Shingo   与五沢　真吾    所属   埼玉医科大学  保健医療学部 臨床検査学科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Structures of the rat proteasomal ATPases: Determination of highly conserved structural motifs and rules for their spacing
掲載誌名	正式名：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSNコード：0006-291X
出版社	ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
巻・号・頁	220(3),1049-1054頁
著者・共著者	Y Makino,S Yogosawa,M Kanemaki,T Yoshida,K Yamano,T Kishimoto,Moncollin, V,JM Egly,M Muramatsu,T Tamura
発行年月	1996/03
概要	We have isolated rat cDNAs for all of the five known proteasomal ATPases. The protein sequences of rat TBP1, TBP7, MSS1, S4, and SUG1 predicted from the open reading frames consist of 439, 418, 433, 440, and 406 amino acid residues, respectively, and exhibit striking similarities to each human counterpart with only several amino acid substitutions. These five rat ATPases are also highly homologous with each other. The N-terminal region in rat TBP1, TBP7, and SUG1 contains a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Also, in the central region of each rat ATPase, we found four conserved motifs, Gx4GKT, DEID, SAT, and H/QRxGRx2R, that are characteristic of a large family of ATP-dependent RNA/DNA helicases. The spacing between individual moths was strictly conserved in the rat ATPases. These findings suggest a common function of the rat proteasomal ATPases in ATP-dependent RNA/DNA unwinding. (C) 1996 Academic Press, Inc.
DOI	10.1006/bbrc.1996.0530
NAID	80008931954
PMID	8607789