ヨゴサワ　シンゴ   YOGOSAWA Shingo   与五沢　真吾    所属   埼玉医科大学  保健医療学部 臨床検査学科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G(2)/M arrest
掲載誌名	正式名：BIOLOGICAL & PHARMACEUTICAL BULLETIN ISSNコード：0918-6158
出版社	PHARMACEUTICAL SOC JAPAN
巻・号・頁	28(5),849-853頁
著者・共著者	T Maeda,Y Nagaoka,Y Kawai,N Takagaki,C Yasuda,S Yogosawa,Y Sowa,T Sakai,S Uesato
発行年月	2005/05
概要	Two compounds were synthesized which have a structural component other than those of our new series histone deacetylase (HDAC) inhibitors to determine the structure-activity relationship. It was also examined whether the inhibitory effects on cancer cell proliferation by HDAC inhibitors involve p21/WAF1 induction and G(1) or G(2)/M arrest in p53-mutated MG63 human osteosarcoma cells as do other HDAC inhibitors. It was demonstrated that inhibitors with the 2-naphthylcarbonyl group and hydroxamic acid at both termimal sides as well as the phenylene component at the center of molecule markedly induce the p21/WAF1 protein by stimulating p21/WAF1 gene promoter activity. Furthermore, cell cycle analysis revealed that these compounds arrest MG63 cells in the G(2)/M phase.
DOI	10.1248/bpb.28.849
NAID	10016663305
PMID	15863892