ヨゴサワ　シンゴ   YOGOSAWA Shingo   与五沢　真吾    所属   埼玉医科大学  保健医療学部 臨床検査学科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL
掲載誌名	正式名：INTERNATIONAL JOURNAL OF ONCOLOGY ISSNコード：1019-6439/1791-2423
出版社	SPANDIDOS PUBL LTD
巻・号・頁	46(1),389-394頁
著者・共著者	Qi Sun,Shingo Yogosawa,Yosuke Iizumi,Toshiyuki Sakai,Yoshihiro Sowa
発行年月	2015/01
概要	Cisplatin and its platinum derivatives are first-line chemotherapeutic agents in the treatment of ovarian cancer. However, chemoresistance is the leading cause of therapeutic failure and is responsible for the poor overall survival rate. Here, we describe that emetine, a natural alkaloid used as an anti-amoebiasis drug, sensitized ovarian carcinoma cells to apoptosis induced by cisplatin. The single administration of cisplatin or emetine had a weak effect on cell death. However, co-treatment of cisplatin and emetine remarkably induced apoptosis and reduced the colony formation of ovarian carcinoma cells. Moreover, we showed that apoptosis induced by the combination of cisplatin and emetine was dependent on the activation of caspases-3, -7 and -8. As to the mechanism, downregulation of bcl-xL by emetine was shown to be responsible for enhancing the sensitivity of ovarian cancer cells to cisplatin. These findings suggest that the combination of cisplatin and emetine might be a promising treatment for ovarian cancer.
DOI	10.3892/ijo.2014.2703
PMID	25310746