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イマイ カズオ
IMAI Kazuo
今井 一男 所属 埼玉医科大学 医学部 臨床検査医学（中央検査部） 職種 専任講師 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Clinical response to liposomal doxorubicin and rituximab in HHV-8-associated multicentric Castleman's disease in an HIV-positive patient |
| 掲載誌名 | 正式名：JOURNAL OF INFECTION AND CHEMOTHERAPY ISSNコード：1341321X |
| 出版社 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 22(12),804-807頁 |
| 著者・共著者 | Morichika Osa,Takuya Maeda,Kazuhisa Misawa,Kazuo Imai,Yuji Fujikura,Akihiko Kawana |
| 発行年月 | 2016/12 |
| 概要 | We report a patient with HIV-associated multicentric Castleman's disease who had recurrent human herpesvirus-8 viremia associated with intermittent febrile exanthema and lymphadenopathy. Although the patient relapsed after single-agent treatment with liposomal doxorubicin, weekly infusions of rituximab led to complete remission even though the reactivation of the Kaposi's sarcoma was unfortunately observed. Rituximab could not only eliminate the accumulation of HHV-8 load but also play a part in the modulation of dysregulated CD20-positive B cells in HIV-associated multicentric Castleman's disease. (C) 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.jiac.2016.06.004 |
| PMID | 27373909 |