イマイ　カズオ   IMAI Kazuo   今井　一男    所属   埼玉医科大学  医学部 臨床検査医学（中央検査部）    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan
掲載誌名	正式名：BMC Research Notes ISSNコード：17560500
出版社	BioMed Central Ltd.
巻・号・頁	11(1),53頁
著者・共著者	Kazuhisa Misawa,Norihito Tarumoto,Shinsuke Tamura,Morichika Osa,Takaaki Hamamoto,Atsushi Yuki,Yuji Kouzaki,Kazuo Imai,Runtuwene Lucky Ronald,Toshiyuki Yamaguchi,Takashi Murakami,Shigefumi Maesaki,Yutaka Suzuki,Akihiko Kawana,Takuya Maeda
発行年月	2018/01
概要	Objective: β-Lactamase-negative ampicillin-resistant Haemophilus influenzae is a common opportunistic pathogen of hospital- and community-acquired infections, harboring multiple single nucleotide polymorphisms in the ftsI gene, which codes for penicillin-binding protein-3. The objectives of this study were to perform comprehensive genetic analyses of whole regions of the penicillin-binding proteins in H. influenzae and to identify additional single nucleotide polymorphisms related to antibiotic resistance, especially to ampicillin and other cephalosporins. Results: In this genome analysis of the ftsI gene in 27 strains of H. influenzae, 10 of 23 (43.5%) specimens of group III genotype β-lactamase-negative ampicillin-resistant H. influenzae were paradoxically classified as ampicillin-sensitive phenotypes. Unfortunately, we could not identify any novel mutations that were significantly associated with ampicillin minimum inhibitory concentrations in other regions of the penicillin-binding proteins, and we reconfirmed that susceptibility to β-lactam antibiotics was mainly defined by previously reported SNPs in the ftsI gene. We should also consider detailed changes in expression tha
DOI	10.1186/s13104-018-3169-0
PMID	29352811