イマイ　カズオ   IMAI Kazuo   今井　一男    所属   埼玉医科大学  医学部 臨床検査医学（中央検査部）    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Failure of Liposomal-amphotericin B Treatment for New World Cutaneous Leishmaniasis due to Leishmania braziliensis.
掲載誌名	正式名：Internal medicine (Tokyo, Japan)
巻・号・頁	59(9),1227-1230頁
著者・共著者	Atsushi Kosaka,Naoya Sakamoto,Mayu Hikone,Kazuo Imai,Masayuki Ota,Takuya Washino,Takuya Maeda,Sentarou Iwabuchi
発行年月	2020
概要	Liposomal-amphotericin B (L-AmB) is used for cutaneous leishmaniasis (CL); however, its treatment failure has not yet been described in detail. A 58-year-old man returned from the Republic of Venezuela with a cutaneous ulcer on his left lower leg. The causative pathogen was Leishmania braziliensis. Westarted L-AmB 3 mg/kg/day for 6 days; however, the ulcer did not resolve. The patient was successfully retreated with a higher dose L-AmB 4 mg/kg/day 9 times (total, 36 mg/kg). If L-AmB fails to treat CL and other therapeutics cannot be used, increasing the L-AmB dose is a viable option.
DOI	10.2169/internalmedicine.4096-19
PMID	32378656