イマイ　カズオ   IMAI Kazuo   今井　一男    所属   埼玉医科大学  医学部 臨床検査医学（中央検査部）    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Cross-reactive humoral immune responses against seasonal human coronaviruses in COVID-19 patients with different disease severities.
掲載誌名	正式名：International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
巻・号・頁	111,68-75頁
著者・共著者	Kazuo Imai,Masaru Matsuoka,Sakiko Tabata,Yutaro Kitagawa,Mayu Nagura-Ikeda,Katsumi Kubota,Ai Fukada,Tomohito Takada,Momoko Sato,Sakiko Noguchi,Shinichi Takeuchi,Noriaki Arakawa,Kazuyasu Miyoshi,Yoshiro Saito,Takuya Maeda
発行年月	2021/10
概要	BACKGROUND: The cross-reactive antibody response against seasonal human coronaviruses (HCoVs) was evaluated according to disease severity in patients with COVID-19 in Japan. METHODS: In total, 194 paired serum samples collected from 97 patients with COVID-19 (mild, 35; severe, 62) were analyzed on admission and during convalescence. IgG antibodies against the nucleocapsid (N) and spike (S) proteins of SARS-CoV-2 and four seasonal HCoVs (HCoV-NL63, -229E, -OC43, and -HKU1) were detected by enzyme-linked immunosorbent assays. RESULTS: There was no difference in optical density (OD) values for seasonal HCoVs on admission between the severe and mild cases. In addition, a specific pattern of disease severity-associated OD values for HCoVs was not identified. Significant increases in OD values from admission to convalescence for HCoV-HKU1and -OC43 IgG-S, and for HCoV-NL63 and -229E IgG-N were observed in the severe cases. Significant differences were observed between the mild and severe cases for HCoV-HKU1 and -OC43 IgG-S OD values during convalescence. Correlations were found between the fold changes for HCoV-OC43 IgG-S OD values, and for SARS-CoV-2 IgG-S OD values, and C-reactive prote
DOI	10.1016/j.ijid.2021.08.026
PMID	34407480