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イマイ カズオ
IMAI Kazuo
今井 一男 所属 埼玉医科大学 医学部 臨床検査医学（中央検査部） 職種 専任講師 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Evaluation of a chemiluminescent enzyme immunoassay-based high-throughput SARS-CoV-2 antigen assay for the diagnosis of COVID-19: The VITROS® SARS-CoV-2 Antigen Test. |
| 掲載誌名 | 正式名：Journal of medical virology |
| 巻・号・頁 | 93(12),6778-6781頁 |
| 著者・共著者 | Nanako Matsuzaki,Yuta Orihara,Masahiro Kodana,Yutaro Kitagawa,Masaru Matsuoka,Rieko Kawamura,Shinichi Takeuchi,Kazuo Imai,Norihito Tarumoto,Shigefumi Maesaki,Takuya Maeda |
| 発行年月 | 2021/12 |
| 概要 | A high-throughput, fully automated antigen detection test for SARS-CoV-2 is a viable alternative to reverse-transcription polymerase chain reaction (RT-qPCR) for mass screening during outbreaks. In this study, we compared RT-qPCR for viral load and the VITROS® SARS-CoV-2 Antigen Test with reference to the results of the LUMIPULSE® SARS-CoV-2 Ag Test. Of 128 nasopharyngeal swab specimens taken from patients suspected of being infected with SARS-CoV-2, 49 were positive and 79 were negative according to RT-qPCR. Consistent dose-dependent detection with VITROS® assay was successfully achieved when using nasopharyngeal swab specimens with Ct values of 32.0 or lesser, whereas the CLEIA-based LUMIPULSE® assay was able to detect lower viral loads compared with the VITROS® assay. Our results show that the performance of the VITROS® assay was satisfactory for the diagnosis of contagious COVID-19 patients in the clinical setting. Highlights The performance of the VITROS® SARS-CoV-2 Antigen Test was sufficient for the diagnosis of contagious COVID-19. This test showed high sensitivity and specificity in the detection of SARS-CoV-2 in samples with a Ct value of 32 or less. |
| DOI | 10.1002/jmv.27153 |
| PMID | 34170555 |