イマイ　カズオ   IMAI Kazuo   今井　一男    所属   埼玉医科大学  医学部 臨床検査医学（中央検査部）    職種   専任講師
論文種別	学術雑誌(原著)
言語種別
査読の有無	査読なし
表題	Timing of Initiation of Methylprednisolone Pulse Therapy in Patients with COVID-19
掲載誌名	正式名：COVID
出版社	MDPI AG
巻・号・頁	2(5),532-539頁
著者・共著者	Mieko Tokano,Norihito Tarumoto,Kazuo Imai,Jun Sakai,Noriomi Ishibashi,Kazuhiro Yokota,Hideto Nakayama,Yoshiyuki Haga,Shigefumi Maesaki
発行年月	2022/04
概要	High-dose methylprednisolone pulse therapy is widely used in patients with severe COVID-19. This therapy is known to have sufficient clinical effectiveness, but the optimal administration method is not known. In this study, we assessed the deterioration of oxygenation after methylprednisolone pulse therapy in patients with COVID-19 according to disease severity (oxygen requirement) at initiation of therapy. Ninety-nine patients with COVID-19 who received methylprednisolone pulse therapy at Saitama Medical University Hospital in Japan between October 2020 and October 2021 were retrospectively reviewed. Clinical outcomes were compared according to the fraction of inspired oxygen as a measure of disease severity at initiation of methylprednisolone pulse therapy. Based on the FIO2 level at initiation of methylprednisolone pulse therapy, patients were classified into an early treatment group (FIO2 ≤ 0.39; n = 21), a middle treatment group (FIO2 0.40–0.69; n = 38), and a late treatment group (FIO2 ≥ 0.70; n = 40). The frequency of administration of mechanical ventilation and the days of oxygen therapy in the middle group were lower than in the other groups. The frequency of adverse
DOI	10.3390/covid2050039
PermalinkURL	https://www.mdpi.com/2673-8112/2/5/39/pdf