イマイ　カズオ   IMAI Kazuo   今井　一男    所属   埼玉医科大学  医学部 臨床検査医学（中央検査部）    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Incidence and Risk Factors of Immediate Hypersensitivity Reactions and Immunisation Stress-related Responses with COVID-19 mRNA Vaccine.
掲載誌名	正式名：The journal of allergy and clinical immunology. In practice
著者・共著者	Kazuo Imai,Fumika Tanaka,Shuichi Kawano,Kotoba Esaki,Junko Arakawa,Takashi Nishiyama,Soichiro Seno,Kosuke Hatanaka,Takao Sugiura,Yu Kodama,Seigo Yamada,Shinichiro Iwamoto,Shigeto Takesima,Nobujiro Abe,Chikako Kamae,Shigeaki Aono,Toshimitsu Ito,Tetsuo Yamamoto,Yasunori Mizuguchi
発行年月	2022/08
概要	BACKGROUND: With the implementation of mass vaccination campaigns against COVID-19, the safety of vaccine needs to be evaluated. OBJECTIVE: We aimed to assess the incidence and risk factors for immediate hypersensitivity reactions (IHSR) and immunisation stress-related responses (ISRR) with the Moderna COVID-19 vaccine. METHODS: This nested case-control study included recipients who received the Moderna vaccine at a mass vaccination centre, Japan. Recipients with IHSR and ISRR were designated ascases 1 and 2, respectively. Controls 1 and 2 were selected from recipients without IHSR or ISRR and matched (1 case: 4 controls) with cases 1 and cases 2, respectively. Conditional logistic regression analysis was used to identify risk factors associated with IHSR and ISRR. RESULTS: Of the 614,151 vaccine recipients who received 1,201,688 vaccine doses, 306 recipients (cases 1) and 2,478 recipients (cases 2) showed 318 events of IHSR and 2,558 events of ISRR, respectively. The incidence rates per million doses were estimated as - IHSR: 266 cases, ISRR: 2,129 cases, anaphylaxis: 2 cases, and vasovagal syncope: 72 cases. Risk factors associated with IHSR included female, asthma, atopic derma
DOI	10.1016/j.jaip.2022.07.027
PMID	35953016