カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Guillain-Barre syndrome with antibody to a ganglioside, N-acetylgalactosaminyl GD1a
掲載誌名	正式名：BRAIN ISSNコード：00068950
出版社	OXFORD UNIV PRESS
巻・号・頁	123,116-124頁
著者・共著者	K Kaida,S Kusunoki,K Kamakura,K Motoyoshi,Kanazawa, I
発行年月	2000/01
概要	A retrospective case study of 33 Guillain-Barre syndrome (GBS) patients with the antibody to the ganglioside N-acetylgalactosaminyl GD1a (Ga1NAc-GD1a) was made to investigate the clinical features of GBS with this antibody. Patients were classified into three groups: (i) 25 with IgG antibody (group G, titre greater than or equal to 1:40); (ii) 16 With high-titre IgG antibody (group G-high, titre greater than or equal to 1:320; selected from group G patients), and (iii) eight with IgM antibody but without elevation of IgG (group M, normal range<1:40 for both IgM and IgG), The control group consisted of 72 GBS patients without anti-Ga1NAc-GD1a antibody. Compared with the control group, the G-high and G group patients were characterized as having had antecedent gastrointestinal infection (87% and 72% versus 31%, both P< 0.001), uncommon cranial nerve involvement (19% and 36% versus 54%, P = 0.02 and 0.2, respectively), distal-dominant weakness (94% and 68% versus 36%, P< 0.001 and P = 0.01, respectively) and no sensory signs (81 % and 60 % versus 25 %, P< 0.001 and P = 0.003, respectively), Electrophysiological findings indicative of axonal dysfunction were significant