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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Anti-ganglioside complex antibodies associated with severe disability in GBS |
| 掲載誌名 | 正式名：Journal of Neuroimmunology ISSNコード：01655728 |
| 巻・号・頁 | 182(1-2),212-218頁 |
| 著者・共著者 | K. Kaida,D. Morita,M. Kanzaki,K. Kamakura,K. Motoyoshi,M. Hirakawa,S. Kusunoki |
| 発行年月 | 2007/01 |
| 概要 | Ganglioside complexes (GSCs) are known as target antigens in Guillain-Barré syndrome (GBS). To elucidate the clinical importance of the anti-GSC antibodies in GBS, we investigated serum antibodies to GSCs containing two of the gangliosides, GM1, GD1a, GD1b and GT1b, and analyzed clinical features of anti-GSC-positive GBS patients. Thirty-nine (17%) of 234 GBS patients had IgG anti-GSC antibodies. Anti-GSC-positive GBS had antecedent gastrointestinal infection and lower cranial nerve deficits more frequently than control GBS. The presence of antibody specificity to GD1a/GD1b and/or GD1b/GT1b was significantly associated with severe disability and a requirement for mechanical ventilation. © 2006 Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.jneuroim.2006.09.013 |
| PMID | 17113161 |