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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Antibodies to ganglioside complexes consisting of asialo-GM1 and GQ1b or GT1a in Fisher and Guillain-Barré syndromes |
| 掲載誌名 | 正式名：Journal of Neuroimmunology ISSNコード：01655728 |
| 巻・号・頁 | 214(1-2),125-127頁 |
| 著者・共著者 | Go Ogawa,Ken-ichi Kaida,Susumu Kusunoki,Masami Ueda,Fumihiko Kimura,Keiko Kamakura |
| 発行年月 | 2009/09 |
| 概要 | To determine the epitopes of ganglioside complexes (GSCs) containing GQ1b or GT1a, we investigated their reactivity to GSCs consisting of asialo-GM1 (GA1) and GQ1b or GT1a using IgG anti-GQ1b- or anti-GT1a-positive sera. Nine anti-GQ1b-positive sera had higher activity to GA1/GQ1b than to GQ1b, only five of which reacted with GM1/GQ1b and GD1b/GQ1b. Five of 14 sera positive for GA1/GT1a and GM1/GT1a were negative for GA1/GQ1b and GM1/GQ1b. Sialic acids attached to the internal galactose of gangliotetraose can influence the reactivity of anti-GSC antibodies. Screening for antibodies to GSCs containing GA1 is useful for elucidation of the antibody-mediated pathophysiology. © 2009 Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.jneuroim.2009.06.017 |
| PMID | 19631994 |