カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Nationwide survey of patients in Japan with Bickerstaff brainstem encephalitis: Epidemiological and clinical characteristics
掲載誌名	正式名：Journal of Neurology, Neurosurgery and Psychiatry ISSNコード：00223050
巻・号・頁	83(12),1210-1215頁
著者・共著者	Michiaki Koga,Susumu Kusunoki,Kenichi Kaida,Ritei Uehara,Yosikazu Nakamura,Tatsuo Kohriyama,Takashi Kanda
発行年月	2012/12
概要	Backgroud: Information regarding the epidemiological background of Bickerstaff brainstem encephalitis (BBE) is limited. Methods: We conducted a nationwide survey of BBE in the Japanese population in two steps: the first aimed to identify patients with brainstem encephalitis for the specified 3 year period and the second to evaluate whether the clinical picture met our diagnostic criteria for BBE. Results: The number of patients with brainstem encephalitis was estimated as 704 (95% CI 478 to 930) over the 3 years. The annual onset of BBE was roughly estimated as 100 cases, which accounted for 43% of brainstem encephalitis. BBE was slightly male predominant and often young onset. Among brainstem encephalitis patients, BBE was characterised by antecedent infectious symptoms, oropharyngeal palsy and sensory disturbance at the distal extremities with absent or decreased tendon reflexes, in addition to a triad of symptoms (external ophthalmoplegia, ataxia and impaired level of consciousness) and shorter duration to the peak, with good outcome. Anti-GQ1b antibodies were present in 75% of cases. Several BBE patients with atypical clinical features or without anti- GQ1b antibodies were also
DOI	10.1136/jnnp-2012-303060
PMID	22851608